Features of immunopathogenesis of a new coronavirus infection

The main biological characteristics of viruses the Coronaviridae family are presented. features immunopathogenesis these infections analyzed. It was found that structural proteins spine, membrane, envelope and nucleocapsid play an important role in COVID-19 infection. They associated with hyperactivation neutrophils monocytes-macrophages, secreting large amounts pro-inflammatory cytokines chemokines. This contributes to development a cytokine storm unfavorable prognosis disease. A particularly high risk developing pneumonia exists against background increase production of: macrophage inflammatory protein-1 alpha, chemotactic protein, interleukin 8. At height infection some patients, macrophages dendritic cells infected SARS-CoV-2 lose their ability produce type I interferons cytokines. On part cellular immunity, significant decrease number CD4+ CD8+-lymphocytes noted. Among IgG sub-isotypes, IgG3 antibodies had highest reactivity, IgG1 were less reactive. Antibodies spike protein low specificity or titer do not neutralize virus contribute contamination immunocompetent via Fc receptors. Low-affinity levels can increased cell sensitivity severe forms